Neuroprotective & Cognitive Peptides
Peptides studied for cognitive enhancement, neuroprotection, and neurological conditions. Includes nootropic peptides and sleep-related compounds.
Neuroprotective peptides represent a diverse group studied for their effects on brain-derived neurotrophic factor (BDNF), neuroplasticity, stroke recovery, and cognitive function. Several compounds in this category (Semax, Selank) are approved medications in Russia but lack Western clinical validation.
Semax
Evidence Tier: Limited Human Data (Russia-approved) — Semax is a synthetic analog of ACTH(4-10) with an added Pro-Gly-Pro tripeptide. It is approved in Russia for stroke recovery and cognitive disorders but has no Western clinical validation.
Selank
Evidence Tier: Limited Human Data (Russia-approved) — Selank is a synthetic analog of the immunomodulatory peptide tuftsin with an added Pro-Gly-Pro sequence. Approved in Russia as an anxiolytic nasal spray.
DSIP (Delta Sleep-Inducing Peptide)
Evidence Tier: Preclinical — DSIP is a naturally occurring nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) that was first isolated from rabbit brain during slow-wave (delta) sleep. Also known as Emideltide. Under FDA review for 2026 reclassification.